American Airlines flight AA 5388: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 10:00 Ronald Reagan Washington (DCA) 2 11:55 Des Moines (DSM)
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:55 Valid until 2025-05-04
Daily 10:00 Ronald Reagan Washington (DCA) 2 11:59 Des Moines (DSM)
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:59 Effective 2025-11-02 through 2025-12-02
Daily 10:00 Ronald Reagan Washington (DCA) 2 11:53 Des Moines (DSM)
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:53 Effective 2025-12-03 through 2025-12-17
Daily 10:00 Ronald Reagan Washington (DCA) 2 11:48 Des Moines (DSM)
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:48 Effective 2025-12-18 through 2026-01-05
Daily 10:09 Ronald Reagan Washington (DCA) 2 12:11 Des Moines (DSM)
AA 5388 Non-stop Canadair CRJ 700 (CR7) 3:02 Effective 2026-01-06 through 2026-02-11
Daily 10:09 Ronald Reagan Washington (DCA) 2 12:21 Des Moines (DSM)
AA 5388 Non-stop Canadair CRJ 700 (CR7) 3:12 Effective from 2026-02-12
Daily 10:23 Ronald Reagan Washington (DCA) 2 12:18 Des Moines (DSM)
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:55 Effective 2025-05-05 through 2025-06-04
Daily 12:23 Des Moines (DSM) 15:55 Ronald Reagan Washington (DCA) 2
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:32 Effective 2025-12-03 through 2025-12-17
Daily 12:25 Des Moines (DSM) 15:53 Ronald Reagan Washington (DCA) 2
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:28 Valid until 2025-05-04
Daily 12:26 Des Moines (DSM) 15:59 Ronald Reagan Washington (DCA) 2
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:33 Effective 2025-12-18 through 2026-01-05
Daily 12:29 Des Moines (DSM) 15:59 Ronald Reagan Washington (DCA) 2
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:30 Effective 2025-11-02 through 2025-12-02
Daily 12:48 Des Moines (DSM) 16:19 Ronald Reagan Washington (DCA) 2
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:31 Effective 2025-05-05 through 2025-06-04
Daily 12:59 Ronald Reagan Washington (DCA) 2 14:48 Des Moines (DSM)
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:49 Effective 2025-10-06 through 2025-11-01
Daily 13:00 Des Moines (DSM) 16:29 Ronald Reagan Washington (DCA) 2
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:29 Effective from 2026-02-12
Daily 13:04 Des Moines (DSM) 16:29 Ronald Reagan Washington (DCA) 2
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:25 Effective 2026-01-06 through 2026-02-11
Daily 13:44 Ronald Reagan Washington (DCA) 2 15:18 Des Moines (DSM)
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:34 Effective 2025-08-06 through 2025-09-02
Daily 13:44 Ronald Reagan Washington (DCA) 2 15:20 Des Moines (DSM)
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:36 Effective 2025-09-03 through 2025-10-05
Daily 15:45 Des Moines (DSM) 19:15 Ronald Reagan Washington (DCA) 2
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:30 Effective 2025-08-06 through 2025-10-05
Daily 15:54 Des Moines (DSM) 19:15 Ronald Reagan Washington (DCA) 2
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:21 Effective 2025-10-06 through 2025-11-01
Daily 19:59 Ronald Reagan Washington (DCA) 2 21:28 Destin/Fort Walton Beach (VPS)
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:29 Effective 2025-06-05 through 2025-07-03
Daily 19:59 Ronald Reagan Washington (DCA) 2 21:34 Destin/Fort Walton Beach (VPS)
AA 5388 Non-stop Canadair CRJ 700 (CR7) 2:35 Effective 2025-07-05 through 2025-08-05
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This flight number is listed as serving the following routes:


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American Airlines flight AA 5388: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA5388
10:00
Ronald Reagan Washington (DCA) 2

11:55
Des Moines (DSM)
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:55, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
10:00
Ronald Reagan Washington (DCA) 2

11:59
Des Moines (DSM)
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:59, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
10:00
Ronald Reagan Washington (DCA) 2

11:53
Des Moines (DSM)
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:53, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
10:00
Ronald Reagan Washington (DCA) 2

11:48
Des Moines (DSM)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:48, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
10:09
Ronald Reagan Washington (DCA) 2

12:11
Des Moines (DSM)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:02, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
10:09
Ronald Reagan Washington (DCA) 2

12:21
Des Moines (DSM)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:12, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
10:23
Ronald Reagan Washington (DCA) 2

12:18
Des Moines (DSM)
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:55, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
12:23
Des Moines (DSM)

15:55
Ronald Reagan Washington (DCA) 2
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:32, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
12:25
Des Moines (DSM)

15:53
Ronald Reagan Washington (DCA) 2
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:28, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
12:26
Des Moines (DSM)

15:59
Ronald Reagan Washington (DCA) 2
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:33, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
12:29
Des Moines (DSM)

15:59
Ronald Reagan Washington (DCA) 2
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:30, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
12:48
Des Moines (DSM)

16:19
Ronald Reagan Washington (DCA) 2
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:31, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
12:59
Ronald Reagan Washington (DCA) 2

14:48
Des Moines (DSM)
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:49, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
13:00
Des Moines (DSM)

16:29
Ronald Reagan Washington (DCA) 2
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:29, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
13:04
Des Moines (DSM)

16:29
Ronald Reagan Washington (DCA) 2
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:25, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
13:44
Ronald Reagan Washington (DCA) 2

15:18
Des Moines (DSM)
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:34, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
13:44
Ronald Reagan Washington (DCA) 2

15:20
Des Moines (DSM)
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:36, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
15:45
Des Moines (DSM)

19:15
Ronald Reagan Washington (DCA) 2
Effective 2025-08-06 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:30, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
15:54
Des Moines (DSM)

19:15
Ronald Reagan Washington (DCA) 2
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:21, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
19:59
Ronald Reagan Washington (DCA) 2

21:28
Destin/Fort Walton Beach (VPS)
Effective 2025-06-05 through 2025-07-03
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:29, non-stop
Canadair CRJ 700 (CR7)
American Airlines AA5388
19:59
Ronald Reagan Washington (DCA) 2

21:34
Destin/Fort Walton Beach (VPS)
Effective 2025-07-05 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:35, non-stop
Canadair CRJ 700 (CR7)
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This flight number is listed as serving the following routes:
  • Ronald Reagan Washington (DCA) - Des Moines (DSM)
  • Ronald Reagan Washington (DCA) - Destin/Fort Walton Beach (VPS)
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