American Airlines flight AA 4281: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 16:30 Charleston (CHS) 18:00 Chicago O'Hare (ORD) 3
AA 4281 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:30 Effective from 2026-02-12
Daily 20:40 Dallas Fort Worth (DFW) 22:01 Amarillo (AMA)
AA 4281 Non-stop Embraer EMB 175 (E75) 1:21 Effective 2025-11-02 through 2025-12-02
Daily 20:40 Dallas Fort Worth (DFW) 22:07 Amarillo (AMA)
AA 4281 Non-stop Embraer EMB 175 (E75) 1:27 Effective 2025-12-03 through 2025-12-17
Daily 20:40 Dallas Fort Worth (DFW) 22:08 Amarillo (AMA)
AA 4281 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:28 Effective 2025-12-18 through 2026-01-05
Daily 20:40 Dallas Fort Worth (DFW) 21:59 Amarillo (AMA)
AA 4281 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:19 Effective 2026-01-06 through 2026-02-11
Daily 20:43 Dallas Fort Worth (DFW) 22:05 Amarillo (AMA)
AA 4281 Non-stop Embraer EMB 175 (E75) 1:22 Effective 2025-10-26 through 2025-11-01
Daily 21:46 Chicago O'Hare (ORD) 3 23:50 Tulsa (TUL)
AA 4281 Non-stop Embraer EMB 175 (E75) 2:04 Effective 2025-07-05 through 2025-10-05
Daily 22:10 Chicago O'Hare (ORD) 3 23:59 Tulsa (TUL)
AA 4281 Non-stop Embraer EMB 175 (E75) 1:49 Effective 2025-06-05 through 2025-06-30
Thu 22:10 Chicago O'Hare (ORD) 3 23:59 Tulsa (TUL)
AA 4281 Non-stop Embraer EMB 175 (E75) 1:49 Operates only on 2025-07-03
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4281: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4281
16:30
Charleston (CHS)

18:00
Chicago O'Hare (ORD) 3
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:30, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4281
20:40
Dallas Fort Worth (DFW)

22:01
Amarillo (AMA)
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:21, non-stop
Embraer EMB 175 (E75)
American Airlines AA4281
20:40
Dallas Fort Worth (DFW)

22:07
Amarillo (AMA)
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:27, non-stop
Embraer EMB 175 (E75)
American Airlines AA4281
20:40
Dallas Fort Worth (DFW)

22:08
Amarillo (AMA)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:28, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4281
20:40
Dallas Fort Worth (DFW)

21:59
Amarillo (AMA)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:19, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4281
20:43
Dallas Fort Worth (DFW)

22:05
Amarillo (AMA)
Effective 2025-10-26 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:22, non-stop
Embraer EMB 175 (E75)
American Airlines AA4281
21:46
Chicago O'Hare (ORD) 3

23:50
Tulsa (TUL)
Effective 2025-07-05 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:04, non-stop
Embraer EMB 175 (E75)
American Airlines AA4281
22:10
Chicago O'Hare (ORD) 3

23:59
Tulsa (TUL)
Effective 2025-06-05 through 2025-06-30
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:49, non-stop
Embraer EMB 175 (E75)
American Airlines AA4281
22:10
Chicago O'Hare (ORD) 3

23:59
Tulsa (TUL)
Operates only on 2025-07-03
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Duration: 1:49, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Charleston (CHS) - Chicago O'Hare (ORD)
  • Chicago O'Hare (ORD) - Tulsa (TUL)
  • Dallas Fort Worth (DFW) - Amarillo (AMA)
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