American Airlines flight AA 3381: Multiple routes

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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 06:00 Boston Logan (BOS) B 08:26 Saint Louis (STL) 1
AA 3381 Non-stop Embraer EMB 175 (E75) 3:26 Effective 2025-10-06 through 2025-10-25
Daily 07:00 Minneapolis/Saint Paul (MSP) 1 08:48 Chicago O'Hare (ORD) 3
AA 3381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:48 Effective 2025-05-06 through 2025-05-24
Sun 07:00 Minneapolis/Saint Paul (MSP) 1 08:48 Chicago O'Hare (ORD) 3
AA 3381 Non-stop Embraer EMB 175 (E75) 1:48 Operates only on 2025-05-25
Daily 07:00 Minneapolis/Saint Paul (MSP) 1 08:48 Chicago O'Hare (ORD) 3
AA 3381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:48 Effective 2025-05-26 through 2025-06-04
Daily 07:00 Boston Logan (BOS) B 09:14 Saint Louis (STL) 1
AA 3381 Non-stop Embraer EMB 175 (E75) 3:14 Effective 2025-08-06 through 2025-09-02
Daily 07:00 Boston Logan (BOS) B 09:04 Saint Louis (STL) 1
AA 3381 Non-stop Embraer EMB 175 (E75) 3:04 Effective 2025-09-03 through 2025-10-05
Fri 07:08 Boston Logan (BOS) B 09:21 Saint Louis (STL) 1
AA 3381 Non-stop Embraer EMB 175 (E75) 3:13 Operates only on 2025-07-04
Mon-Fri,Sun 07:15 Boston Logan (BOS) B 09:31 Saint Louis (STL) 1
AA 3381 Non-stop Embraer EMB 175 (E75) 3:16 Effective 2025-06-05 through 2025-07-03
Mon-Fri,Sun 07:15 Boston Logan (BOS) B 09:29 Saint Louis (STL) 1
AA 3381 Non-stop Embraer EMB 175 (E75) 3:14 Effective 2025-07-06 through 2025-08-05
Sat 08:00 Boston Logan (BOS) B 10:08 Saint Louis (STL) 1
AA 3381 Non-stop Embraer EMB 175 (E75) 3:08 Effective 2025-06-07 through 2025-08-02
Daily 11:19 Appleton (ATW) 12:40 Chicago O'Hare (ORD) 3
AA 3381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:21 Effective 2025-12-03 through 2025-12-17
Daily 12:20 Chicago O'Hare (ORD) 3 13:30 Wausau (CWA)
AA 3381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:10 Effective 2026-01-07 through 2026-02-11
Daily 16:40 Chicago O'Hare (ORD) 3 19:03 Cleveland Hopkins (CLE)
AA 3381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:23 Effective 2025-10-26 through 2025-11-01
Daily 16:40 Chicago O'Hare (ORD) 3 18:58 Cleveland Hopkins (CLE)
AA 3381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:18 Effective 2025-11-02 through 2025-12-02
Daily 16:40 Chicago O'Hare (ORD) 3 18:54 Cleveland Hopkins (CLE)
AA 3381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:14 Effective from 2026-02-12
Daily 20:20 Chicago O'Hare (ORD) 3 21:26 Bloomington/Normal (BMI)
AA 3381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:06 Effective 2025-12-18 through 2026-01-05
Tue 20:20 Chicago O'Hare (ORD) 3 21:21 Bloomington/Normal (BMI)
AA 3381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:01 Operates only on 2026-01-06
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This flight number is listed as serving the following routes:


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American Airlines flight AA 3381: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA3381
06:00
Boston Logan (BOS) B

08:26
Saint Louis (STL) 1
Effective 2025-10-06 through 2025-10-25
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:26, non-stop
Embraer EMB 175 (E75)
American Airlines AA3381
07:00
Minneapolis/Saint Paul (MSP) 1

08:48
Chicago O'Hare (ORD) 3
Effective 2025-05-06 through 2025-05-24
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:48, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA3381
07:00
Minneapolis/Saint Paul (MSP) 1

08:48
Chicago O'Hare (ORD) 3
Operates only on 2025-05-25
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:48, non-stop
Embraer EMB 175 (E75)
American Airlines AA3381
07:00
Minneapolis/Saint Paul (MSP) 1

08:48
Chicago O'Hare (ORD) 3
Effective 2025-05-26 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:48, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA3381
07:00
Boston Logan (BOS) B

09:14
Saint Louis (STL) 1
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:14, non-stop
Embraer EMB 175 (E75)
American Airlines AA3381
07:00
Boston Logan (BOS) B

09:04
Saint Louis (STL) 1
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:04, non-stop
Embraer EMB 175 (E75)
American Airlines AA3381
07:08
Boston Logan (BOS) B

09:21
Saint Louis (STL) 1
Operates only on 2025-07-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Duration: 3:13, non-stop
Embraer EMB 175 (E75)
American Airlines AA3381
07:15
Boston Logan (BOS) B

09:31
Saint Louis (STL) 1
Effective 2025-06-05 through 2025-07-03
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 3:16, non-stop
Embraer EMB 175 (E75)
American Airlines AA3381
07:15
Boston Logan (BOS) B

09:29
Saint Louis (STL) 1
Effective 2025-07-06 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 3:14, non-stop
Embraer EMB 175 (E75)
American Airlines AA3381
08:00
Boston Logan (BOS) B

10:08
Saint Louis (STL) 1
Effective 2025-06-07 through 2025-08-02
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 3:08, non-stop
Embraer EMB 175 (E75)
American Airlines AA3381
11:19
Appleton (ATW)

12:40
Chicago O'Hare (ORD) 3
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:21, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA3381
12:20
Chicago O'Hare (ORD) 3

13:30
Wausau (CWA)
Effective 2026-01-07 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:10, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA3381
16:40
Chicago O'Hare (ORD) 3

19:03
Cleveland Hopkins (CLE)
Effective 2025-10-26 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:23, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA3381
16:40
Chicago O'Hare (ORD) 3

18:58
Cleveland Hopkins (CLE)
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:18, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA3381
16:40
Chicago O'Hare (ORD) 3

18:54
Cleveland Hopkins (CLE)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:14, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA3381
20:20
Chicago O'Hare (ORD) 3

21:26
Bloomington/Normal (BMI)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:06, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA3381
20:20
Chicago O'Hare (ORD) 3

21:21
Bloomington/Normal (BMI)
Operates only on 2026-01-06
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 1:01, non-stop
Embraer EMB 170 / EMB 175 (E70)
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This flight number is listed as serving the following routes:
  • Appleton (ATW) - Chicago O'Hare (ORD)
  • Boston Logan (BOS) - Saint Louis (STL)
  • Chicago O'Hare (ORD) - Bloomington/Normal (BMI)
  • Chicago O'Hare (ORD) - Cleveland Hopkins (CLE)
  • Chicago O'Hare (ORD) - Wausau (CWA)
  • Minneapolis/Saint Paul (MSP) - Chicago O'Hare (ORD)
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