American Airlines flight AA 2421: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Tue 06:00 Las Vegas Harry Reid (LAS) 1 10:46 Dallas Fort Worth (DFW)
AA 2421 Non-stop Airbus A321 (321) 2:46 Operates only on 2026-01-06
Daily 07:00 Dallas Fort Worth (DFW) 08:13 Las Vegas Harry Reid (LAS) 1
AA 2421 Non-stop Airbus A321 (321) 3:13 Effective 2026-01-07 through 2026-02-11
Daily 08:05 Chicago O'Hare (ORD) 3 10:46 Dallas Fort Worth (DFW)
AA 2421 Non-stop Boeing 737-800 (738) 2:41 Effective 2025-11-02 through 2025-12-02
Daily 09:30 Las Vegas Harry Reid (LAS) 1 14:16 Dallas Fort Worth (DFW)
AA 2421 Non-stop Airbus A321 (321) 2:46 Effective 2026-01-07 through 2026-02-11
Daily 11:10 Charlotte (CLT) 12:21 Chicago O'Hare (ORD) 3
AA 2421 Non-stop Boeing 737-800 (738) 2:11 Effective 2025-10-26 through 2025-11-01
Daily 16:35 Phoenix Sky Harbor (PHX) 4 18:34 San Francisco (SFO) 1
AA 2421 Non-stop Boeing 737-800 (738) 1:59 Effective 2025-08-06 through 2025-09-02
Daily 16:35 Phoenix Sky Harbor (PHX) 4 18:40 San Francisco (SFO) 1
AA 2421 Non-stop Boeing 737-800 (738) 2:05 Effective 2025-09-03 through 2025-10-05
Daily 16:35 Phoenix Sky Harbor (PHX) 4 18:39 San Francisco (SFO) 1
AA 2421 Non-stop Boeing 737-800 (738) 2:04 Effective 2025-10-06 through 2025-10-25
Daily 16:47 Phoenix Sky Harbor (PHX) 4 18:53 San Francisco (SFO) 1
AA 2421 Non-stop Airbus A320 (320) 2:06 Valid until 2025-05-04
Daily 16:55 Phoenix Sky Harbor (PHX) 4 18:58 San Francisco (SFO) 1
AA 2421 Non-stop Airbus A320 (320) 2:03 Effective 2025-05-05 through 2025-06-03
Daily 16:55 Phoenix Sky Harbor (PHX) 4 18:53 San Francisco (SFO) 1
AA 2421 Non-stop Boeing 737-800 (738) 1:58 Effective 2025-06-05 through 2025-07-03
Daily 16:57 Phoenix Sky Harbor (PHX) 4 18:56 San Francisco (SFO) 1
AA 2421 Non-stop Boeing 737-800 (738) 1:59 Effective 2025-07-05 through 2025-08-05
Daily 19:30 New York John F. Kennedy (JFK) 8 21:44 Charlotte (CLT)
AA 2421 Non-stop Airbus A319 (319) 2:14 Effective from 2026-02-12
Daily 20:15 Charlotte (CLT) 20:48 Birmingham (BHM)
AA 2421 Non-stop Airbus A320 (320) 1:33 Effective 2025-12-18 through 2026-01-05
Daily 20:20 Charlotte (CLT) 22:31 Miami (MIA)
AA 2421 Non-stop Boeing 737-800 (738) 2:11 Effective 2025-12-03 through 2025-12-17
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This flight number is listed as serving the following routes:


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American Airlines flight AA 2421: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA2421
06:00
Las Vegas Harry Reid (LAS) 1

10:46
Dallas Fort Worth (DFW)
Operates only on 2026-01-06
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:46, non-stop
Airbus A321 (321)
American Airlines AA2421
07:00
Dallas Fort Worth (DFW)

08:13
Las Vegas Harry Reid (LAS) 1
Effective 2026-01-07 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:13, non-stop
Airbus A321 (321)
American Airlines AA2421
08:05
Chicago O'Hare (ORD) 3

10:46
Dallas Fort Worth (DFW)
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:41, non-stop
Boeing 737-800 (738)
American Airlines AA2421
09:30
Las Vegas Harry Reid (LAS) 1

14:16
Dallas Fort Worth (DFW)
Effective 2026-01-07 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:46, non-stop
Airbus A321 (321)
American Airlines AA2421
11:10
Charlotte (CLT)

12:21
Chicago O'Hare (ORD) 3
Effective 2025-10-26 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:11, non-stop
Boeing 737-800 (738)
American Airlines AA2421
16:35
Phoenix Sky Harbor (PHX) 4

18:34
San Francisco (SFO) 1
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:59, non-stop
Boeing 737-800 (738)
American Airlines AA2421
16:35
Phoenix Sky Harbor (PHX) 4

18:40
San Francisco (SFO) 1
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:05, non-stop
Boeing 737-800 (738)
American Airlines AA2421
16:35
Phoenix Sky Harbor (PHX) 4

18:39
San Francisco (SFO) 1
Effective 2025-10-06 through 2025-10-25
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:04, non-stop
Boeing 737-800 (738)
American Airlines AA2421
16:47
Phoenix Sky Harbor (PHX) 4

18:53
San Francisco (SFO) 1
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:06, non-stop
Airbus A320 (320)
American Airlines AA2421
16:55
Phoenix Sky Harbor (PHX) 4

18:58
San Francisco (SFO) 1
Effective 2025-05-05 through 2025-06-03
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:03, non-stop
Airbus A320 (320)
American Airlines AA2421
16:55
Phoenix Sky Harbor (PHX) 4

18:53
San Francisco (SFO) 1
Effective 2025-06-05 through 2025-07-03
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:58, non-stop
Boeing 737-800 (738)
American Airlines AA2421
16:57
Phoenix Sky Harbor (PHX) 4

18:56
San Francisco (SFO) 1
Effective 2025-07-05 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:59, non-stop
Boeing 737-800 (738)
American Airlines AA2421
19:30
New York John F. Kennedy (JFK) 8

21:44
Charlotte (CLT)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:14, non-stop
Airbus A319 (319)
American Airlines AA2421
20:15
Charlotte (CLT)

20:48
Birmingham (BHM)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:33, non-stop
Airbus A320 (320)
American Airlines AA2421
20:20
Charlotte (CLT)

22:31
Miami (MIA)
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:11, non-stop
Boeing 737-800 (738)
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This flight number is listed as serving the following routes:
  • Charlotte (CLT) - Birmingham (BHM)
  • Charlotte (CLT) - Chicago O'Hare (ORD)
  • Charlotte (CLT) - Miami (MIA)
  • Chicago O'Hare (ORD) - Dallas Fort Worth (DFW)
  • Dallas Fort Worth (DFW) - Las Vegas Harry Reid (LAS)
  • New York John F. Kennedy (JFK) - Charlotte (CLT)
  • Phoenix Sky Harbor (PHX) - San Francisco (SFO)
All American Airlines flights
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